Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

• Juliane Winkelmann ,

  * E-mail: winkelmann@lrz.tu-muenchen.de

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Department of Neurology, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Darina Czamara ,

  Contributed equally to this work with: Darina Czamara, Barbara Schormair

  Affiliation Max Planck Institute of Psychiatry, Munich, Germany

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• Barbara Schormair ,

  Contributed equally to this work with: Darina Czamara, Barbara Schormair

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Franziska Knauf,

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Eva C. Schulte,

  Affiliation Department of Neurology, Technische Universität München, Munich, Germany

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• Claudia Trenkwalder,

  Affiliation Paracelsus-Elena-Hospital, Kassel, Germany

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• Yves Dauvilliers,

  Affiliation Unité du Sommeil, Service de Neurologie, Hôpital Gui-de-Chauliac, INSERM U1061, Montpellier, France

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• Olli Polo,

  Affiliations Department of Pulmonary Medicine, Tampere University Hospital, Tampere, Finland, Sleep Research Unit, University of Turku, Turku, Finland

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• Birgit Högl,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Klaus Berger,

  Affiliation Institute of Epidemiology and Social Medicine, University Münster, Münster, Germany

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• Andrea Fuhs,

  Affiliation Institute of Epidemiology and Social Medicine, University Münster, Münster, Germany

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• Nadine Gross,

  Affiliation Department of Neurology, Technische Universität München, Munich, Germany

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• Karin Stiasny-Kolster,

  Affiliations Somnomar, Sleep Research Institute, Marburg, Germany, Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany

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• Wolfgang Oertel,

  Affiliation Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany

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• Cornelius G. Bachmann,

  Affiliation Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany

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• Walter Paulus,

  Affiliation Department of Clinical Neurophysiology, University of Göttingen, Göttingen, Germany

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• Lan Xiong,

  Affiliation Centre of Excellence in Neuromics, CHUM Research Centre and the Department of Medicine, University of Montreal, Montreal, Canada

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• Jacques Montplaisir,

  Affiliations Laboratoire d'étude des maladies du cerveau, Centre de recherche du CHUM, Hôpital Notre-Dame, Université de Montréal, Montréal, Canada, Centre d'étude du sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada

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• Guy A. Rouleau,

  Affiliation Centre of Excellence in Neuromics, CHUM Research Centre and the Department of Medicine, University of Montreal, Montreal, Canada

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• Ingo Fietze,

  Affiliation Charite – Universitätsmedizin Berlin Interdisciplinary Center of Sleep Medicine, Berlin, Germany

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• Jana Vávrová,

  Affiliation Department of Neurology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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• David Kemlink,

  Affiliation Department of Neurology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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• Karel Sonka,

  Affiliation Department of Neurology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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• Sona Nevsimalova,

  Affiliation Department of Neurology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

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• Siong-Chi Lin,

  Affiliation Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada

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• Zbigniew Wszolek,

  Affiliation Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada

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• Carles Vilariño-Güell,

  Affiliation Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada

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• Matthew J. Farrer,

  Affiliation Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada

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• Viola Gschliesser,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Birgit Frauscher,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Tina Falkenstetter,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Werner Poewe,

  Affiliation Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

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• Richard P. Allen,

  Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Christopher J. Earley,

  Affiliation Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• William G. Ondo,

  Affiliation Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America

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• Wei-Dong Le,

  Affiliation Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America

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• Derek Spieler,

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Maria Kaffe,

  Affiliations Department of Neurology, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Alexander Zimprich,

  Affiliation Department of Neurology, Medical University of Vienna, Vienna, Austria

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• Johannes Kettunen,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Markus Perola,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Kaisa Silander,

  Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Isabelle Cournu-Rebeix,

  Affiliations INSERM, UMR_S975, Paris, France, Centre de Recherche Institut du Cerveau et de la Moelle, CNRS 7225, Paris, France, Fédération des maladies du système nerveux, Pitié – Salpêtrière Hospital, AP-HP, Paris, France

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• Marcella Francavilla,

  Affiliations INSERM, UMR_S975, Paris, France, Centre de Recherche Institut du Cerveau et de la Moelle, CNRS 7225, Paris, France, Fédération des maladies du système nerveux, Pitié – Salpêtrière Hospital, AP-HP, Paris, France

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• Claire Fontenille,

  Affiliations INSERM, UMR_S975, Paris, France, Centre de Recherche Institut du Cerveau et de la Moelle, CNRS 7225, Paris, France, Fédération des maladies du système nerveux, Pitié – Salpêtrière Hospital, AP-HP, Paris, France

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• Bertrand Fontaine,

  Affiliations INSERM, UMR_S975, Paris, France, Centre de Recherche Institut du Cerveau et de la Moelle, CNRS 7225, Paris, France, Fédération des maladies du système nerveux, Pitié – Salpêtrière Hospital, AP-HP, Paris, France

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• Pavel Vodicka,

  Affiliation Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic

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• Holger Prokisch,

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Peter Lichtner,

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Paul Peppard,

  Affiliation Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin, United States of America

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• Juliette Faraco,

  Affiliation Center For Narcolepsy, Stanford University, Palo Alto, California, United States of America

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• Emmanuel Mignot,

  Affiliation Center For Narcolepsy, Stanford University, Palo Alto, California, United States of America

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• Christian Gieger,

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• Thomas Illig,

  Affiliation Unit for Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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• H.-Erich Wichmann,

  Affiliations Institute of Epidemiology I, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Munich, Germany

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• Bertram Müller-Myhsok,

  Affiliation Max Planck Institute of Psychiatry, Munich, Germany

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•  [ ... ],
• Thomas Meitinger

  Affiliations Institute of Human Genetics, Technische Universität München, Munich, Germany, Institute of Human Genetics, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

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