Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals

• Dan E. Arking ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  * E-mail: arking@jhmi.edu (DEA); Sumeet.Chugh@cshs.org (SSC)

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• M. Juhani Junttila ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliations Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland, Division of Cardiology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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• Philippe Goyette ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliation Montreal Heart Institute and the Université de Montréal, Montreal, Canada

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• Adriana Huertas-Vazquez ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Mark Eijgelsheim ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliation Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

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• Marieke T. Blom ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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• Christopher Newton-Cheh ,

  Contributed equally to this work with: Dan E. Arking, M. Juhani Junttila, Philippe Goyette, Adriana Huertas-Vazquez, Mark Eijgelsheim, Marieke T. Blom, Christopher Newton-Cheh

  Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America

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• Kyndaron Reinier,

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Carmen Teodorescu,

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Audrey Uy-Evanado,

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Naima Carter-Monroe,

  Affiliation CVPath Institute, Gaithersburg, Maryland, United States of America

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• Kari S. Kaikkonen,

  Affiliation Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland

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• Marja-Leena Kortelainen,

  Affiliation Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland

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• Gabrielle Boucher,

  Affiliation Montreal Heart Institute and the Université de Montréal, Montreal, Canada

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• Caroline Lagacé,

  Affiliation Montreal Heart Institute and the Université de Montréal, Montreal, Canada

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• Anna Moes,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• XiaoQing Zhao,

  Affiliation CVPath Institute, Gaithersburg, Maryland, United States of America

  ⨯
• Frank Kolodgie,

  Affiliation CVPath Institute, Gaithersburg, Maryland, United States of America

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NCHA), Netherlands Genomic Initiative (NGI), Rotterdam, The Netherlands

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• Albert Hofman,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NCHA), Netherlands Genomic Initiative (NGI), Rotterdam, The Netherlands

  ⨯
• Jacqueline C. M. Witteman,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NCHA), Netherlands Genomic Initiative (NGI), Rotterdam, The Netherlands

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• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NCHA), Netherlands Genomic Initiative (NGI), Rotterdam, The Netherlands

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• Roos F. Marsman,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Raha Pazoki,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Abdennasser Bardai,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Rudolph W. Koster,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Abbas Dehghan,

  Affiliation Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

  ⨯
• Shih-Jen Hwang,

  Affiliation Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America

  ⨯
• Pallav Bhatnagar,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Wendy Post,

  Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Gina Hilton,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Ronald J. Prineas,

  Affiliation Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Man Li,

  Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

  ⨯
• Anna Köttgen,

  Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

  ⨯
• Georg Ehret,

  Affiliations McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland

  ⨯
• Eric Boerwinkle,

  Affiliation University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Josef Coresh,

  Affiliations Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Departments of Medicine and Biostatistics, Johns Hopkins University, Baltimore, Maryland, United States of America

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• W. H. Linda Kao,

  Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Bruce M. Psaty,

  Affiliations Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

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• Gordon F. Tomaselli,

  Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Nona Sotoodehnia,

  Affiliation Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• David S. Siscovick,

  Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Greg L. Burke,

  Affiliation Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

  ⨯
• Eduardo Marbán,

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

  ⨯
• Peter M. Spooner,

  Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• L. Adrienne Cupples,

  Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

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• Jonathan Jui,

  Affiliation Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon, United States of America

  ⨯
• Karen Gunson,

  Affiliation Department of Pathology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Y. Antero Kesäniemi,

  Affiliations Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

  ⨯
• Arthur A. M. Wilde,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Jean-Claude Tardif,

  Affiliation Montreal Heart Institute and the Université de Montréal, Montreal, Canada

  ⨯
• Christopher J. O'Donnell,

  Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

  ⨯
• Connie R. Bezzina,

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Renu Virmani,

  Affiliation CVPath Institute, Gaithersburg, Maryland, United States of America

  ⨯
• Bruno H. C. h. Stricker ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Netherlands Consortium for Healthy Aging (NCHA), Netherlands Genomic Initiative (NGI), Rotterdam, The Netherlands, Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands, Inspectorate of Health Care, The Hague, The Netherlands

  ⨯
• Hanno L. Tan ,

  ¶These authors also contributed equally to this work.

  Affiliation Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Christine M. Albert ,

  ¶These authors also contributed equally to this work.

  Affiliation Center for Arrhythmia Prevention, Division of Preventive Medicine, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Aravinda Chakravarti ,

  ¶These authors also contributed equally to this work.

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• John D. Rioux ,

  ¶These authors also contributed equally to this work.

  Affiliation Montreal Heart Institute and the Université de Montréal, Montreal, Canada

  ⨯
• Heikki V. Huikuri ,

  ¶These authors also contributed equally to this work.

  Affiliation Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland

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•  [ ... ],
• Sumeet S. Chugh

  * E-mail: arking@jhmi.edu (DEA); Sumeet.Chugh@cshs.org (SSC)

  Affiliation The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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