Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

Dirk S. Paul; James P. Nisbet; Tsun-Po Yang; Stuart Meacham; Augusto Rendon; Katta Hautaviita; Jonna Tallila; Jacqui White; Marloes R. Tijssen; Suthesh Sivapalaratnam; Hanneke Basart; Mieke D. Trip; Consortium Cardiogenics; Consortium MuTHER; Berthold Göttgens; Nicole Soranzo; Willem H. Ouwehand; Panos Deloukas

doi:10.1371/journal.pgen.1002139

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Peer-reviewed

Research Article

Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

Dirk S. Paul ,

* E-mail: dp5@sanger.ac.uk (DSP); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
James P. Nisbet,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Tsun-Po Yang,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Stuart Meacham,

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom
⨯
Augusto Rendon,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom, Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom
⨯
Katta Hautaviita,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Jonna Tallila,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Jacqui White,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Marloes R. Tijssen,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Suthesh Sivapalaratnam,

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands
⨯
Hanneke Basart,

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands
⨯
Mieke D. Trip,

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands
⨯
Consortium Cardiogenics ,

¶Memberships of the Cardiogenics and MuTHER Consortia are provided in the Acknowledgments.
⨯
Consortium MuTHER ,

¶Memberships of the Cardiogenics and MuTHER Consortia are provided in the Acknowledgments.
⨯
Berthold Göttgens,

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Nicole Soranzo,

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
⨯
Willem H. Ouwehand,

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom
⨯
[ ... ],
Panos Deloukas

* E-mail: dp5@sanger.ac.uk (DSP); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
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Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

Dirk S. Paul,
James P. Nisbet,
Tsun-Po Yang,
Stuart Meacham,
Augusto Rendon,
Katta Hautaviita,
Jonna Tallila,
Jacqui White,
Marloes R. Tijssen,
Suthesh Sivapalaratnam

Published: June 30, 2011
https://doi.org/10.1371/journal.pgen.1002139

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