RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

Tahsin Stefan Barakat; Nilhan Gunhanlar; Cristina Gontan Pardo; Eskeatnaf Mulugeta Achame; Mehrnaz Ghazvini; Ruben Boers; Annegien Kenter; Eveline Rentmeester; J. Anton Grootegoed; Joost Gribnau

doi:10.1371/journal.pgen.1002001

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Open Access

Peer-reviewed

Research Article

RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

Tahsin Stefan Barakat,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Nilhan Gunhanlar,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Cristina Gontan Pardo,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Eskeatnaf Mulugeta Achame,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Mehrnaz Ghazvini,

Affiliations Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, Erasmus Stem Cell Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Ruben Boers,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Annegien Kenter,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Eveline Rentmeester,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
J. Anton Grootegoed,

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Joost Gribnau

* E-mail: j.gribnau@erasmusmc.nl

Affiliation Department of Reproduction and Development, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯

RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

Tahsin Stefan Barakat,
Nilhan Gunhanlar,
Cristina Gontan Pardo,
Eskeatnaf Mulugeta Achame,
Mehrnaz Ghazvini,
Ruben Boers,
Annegien Kenter,
Eveline Rentmeester,
J. Anton Grootegoed,
Joost Gribnau

Published: January 27, 2011
https://doi.org/10.1371/journal.pgen.1002001

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Cell differentiation
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Introns
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X chromosome inactivation
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Reverse transcriptase-polymerase chain reaction
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Restriction fragment length polymorphism analysis
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Cloning
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Pluripotency
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