Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

Can Cenik; Hon Nian Chua; Hui Zhang; Stefan P. Tarnawsky; Abdalla Akef; Adnan Derti; Murat Tasan; Melissa J. Moore; Alexander F. Palazzo; Frederick P. Roth

doi:10.1371/journal.pgen.1001366

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Peer-reviewed

Research Article

Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

Can Cenik,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Hon Nian Chua,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Hui Zhang,

Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada
⨯
Stefan P. Tarnawsky,

Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada
⨯
Abdalla Akef,

Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada
⨯
Adnan Derti,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Murat Tasan,

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Melissa J. Moore,

Affiliation Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Alexander F. Palazzo ,

* E-mail: alex.palazzo@utoronto.ca (AFP); fritz_roth@hms.harvard.edu (FPR)

Affiliation Department of Biochemistry, University of Toronto, Toronto, Canada
⨯
Frederick P. Roth

* E-mail: alex.palazzo@utoronto.ca (AFP); fritz_roth@hms.harvard.edu (FPR)

Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada
⨯

Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes

Can Cenik,
Hon Nian Chua,
Hui Zhang,
Stefan P. Tarnawsky,
Abdalla Akef,
Adnan Derti,
Murat Tasan,
Melissa J. Moore,
Alexander F. Palazzo,
Frederick P. Roth

Published: April 14, 2011
https://doi.org/10.1371/journal.pgen.1001366

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Sequence motif analysis
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Messenger RNA
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Introns
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Sequence alignment
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