Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster

Christine M. Williamson; Simon T. Ball; Claire Dawson; Stuti Mehta; Colin V. Beechey; Martin Fray; Lydia Teboul; T. Neil Dear; Gavin Kelsey; Jo Peters

doi:10.1371/journal.pgen.1001347

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Open Access

Peer-reviewed

Research Article

Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster

Christine M. Williamson,

Affiliation Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Simon T. Ball,

Affiliation Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Claire Dawson,

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
⨯
Stuti Mehta,

Affiliation Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Colin V. Beechey,

Affiliation Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Martin Fray,

Affiliation Medical Research Council Mary Lyon Centre, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Lydia Teboul,

Affiliation Medical Research Council Mary Lyon Centre, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
T. Neil Dear,

Current address: Section of Experimental Therapeutics, Disease Genetics Group, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

Affiliation Medical Research Council Mary Lyon Centre, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯
Gavin Kelsey,

Affiliations Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
⨯
Jo Peters

* E-mail: j.peters@har.mrc.ac.uk

Affiliation Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, United Kingdom
⨯

Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster

Christine M. Williamson,
Simon T. Ball,
Claire Dawson,
Stuti Mehta,
Colin V. Beechey,
Martin Fray,
Lydia Teboul,
T. Neil Dear,
Gavin Kelsey,
Jo Peters

Published: March 24, 2011
https://doi.org/10.1371/journal.pgen.1001347

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DNA methylation
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Alleles
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Polyadenylation
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Heterozygosity
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Reverse transcriptase-polymerase chain reaction
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Introns
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Methylation
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