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Open Access
Peer-reviewed
Research Article
Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development
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Ulla Sovio ,
Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence
Affiliations Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, The London School of Hygiene and Tropical Medicine, London, United Kingdom
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Dennis O. Mook-Kanamori ,
Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence
Affiliations Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Generation R Study, Erasmus Medical Center, Rotterdam, The Netherlands
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Nicole M. Warrington ,
Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence
Affiliation School of Women's and Infants' Health, The University of Western Australia, Perth, Australia
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Robert Lawrence ,
Contributed equally to this work with: Ulla Sovio, Dennis O. Mook-Kanamori, Nicole M. Warrington, Robert Lawrence
Affiliation Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Perth, Australia
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Laurent Briollais,
Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
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Colin N. A. Palmer,
Affiliation Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
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Joanne Cecil,
Current address: School of Medicine, University of St. Andrews, St. Andrews, United Kingdom
Affiliation Bute Medical School, University of St Andrews, St Andrews, United Kingdom
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Johanna K. Sandling,
Affiliation Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Ann-Christine Syvänen,
Affiliation Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Marika Kaakinen,
Affiliations Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland
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Lawrie J. Beilin,
Affiliation School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia
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Iona Y. Millwood,
Affiliations Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom
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Amanda J. Bennett,
Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Jaana Laitinen,
Affiliation Finnish Institute of Occupational Health, Oulu, Finland
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Anneli Pouta,
Affiliation Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland
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John Molitor,
Affiliation Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom
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George Davey Smith,
Affiliations MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom
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Yoav Ben-Shlomo,
Affiliation Department of Social Medicine, University of Bristol, Bristol, United Kingdom
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Vincent W. V. Jaddoe,
Affiliations Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, The Generation R Study, Erasmus Medical Center, Rotterdam, The Netherlands
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Lyle J. Palmer,
Affiliation Ontario Institute for Cancer Research and Samuel Lunenfeld Research Institute, Toronto, Canada
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Craig E. Pennell,
Affiliation School of Women's and Infants' Health, The University of Western Australia, Perth, Australia
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Tim J. Cole ,
* E-mail: tim.cole@ich.ucl.ac.uk (TJC); n.j.timpson@bristol.ac.uk (NJT)
Affiliation MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom
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Mark I. McCarthy,
Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom
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Marjo-Riitta Järvelin,
Affiliations Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland
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Nicholas J. Timpson ,
* E-mail: tim.cole@ich.ucl.ac.uk (TJC); n.j.timpson@bristol.ac.uk (NJT)
Affiliations MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom, Department of Social Medicine, University of Bristol, Bristol, United Kingdom
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- Early Growth Genetics Consortium
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Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development
- Ulla Sovio,
- Dennis O. Mook-Kanamori,
- Nicole M. Warrington,
- Robert Lawrence,
- Laurent Briollais,
- Colin N. A. Palmer,
- Joanne Cecil,
- Johanna K. Sandling,
- Ann-Christine Syvänen,
- Marika Kaakinen
- Published: February 17, 2011
- https://doi.org/10.1371/journal.pgen.1001307