Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

Elizabeth J. Rossin; Kasper Lage; Soumya Raychaudhuri; Ramnik J. Xavier; Diana Tatar; Yair Benita; International Inflammatory Bowel Disease Genetics Constortium; Chris Cotsapas; Mark J. Daly

doi:10.1371/journal.pgen.1001273

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Research Article

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

Elizabeth J. Rossin,

Affiliations Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Health Science and Technology MD Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, United States of America
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Kasper Lage,

Affiliations Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
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Soumya Raychaudhuri,

Affiliations Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
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Ramnik J. Xavier,

Affiliations Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Diana Tatar,

Affiliation Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Yair Benita,

Affiliation Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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International Inflammatory Bowel Disease Genetics Constortium ,

¶Membership of the International Inflammatory Bowel Disease Genetics Constortium is available in the Acknowledgments.
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Chris Cotsapas ,

Contributed equally to this work with: Chris Cotsapas, Mark J. Daly

Affiliations Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America
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Mark J. Daly

Contributed equally to this work with: Chris Cotsapas, Mark J. Daly

* E-mail: mjdaly@chgr.mgh.harvard.edu

Affiliations Center for Human Genetics Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, The Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Health Science and Technology MD Program, Harvard University and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America, Harvard Biological and Biomedical Sciences Program, Harvard University, Boston, Massachusetts, United States of America
⨯

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

Elizabeth J. Rossin,
Kasper Lage,
Soumya Raychaudhuri,
Ramnik J. Xavier,
Diana Tatar,
Yair Benita,
International Inflammatory Bowel Disease Genetics Constortium,
Chris Cotsapas,
Mark J. Daly

Published: January 13, 2011
https://doi.org/10.1371/journal.pgen.1001273

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14 Jan 2011
08:56 GMT
Most Recent

Genetics of immune system Posted by Leonid on 14 Jan 2011 at 08:56 GMT

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