The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

James F. Theis; Carmela Irene; Ann Dershowitz; Renee L. Brost; Michael L. Tobin; Fabiana M. di Sanzo; Jian-Ying Wang; Charles Boone; Carol S. Newlon

doi:10.1371/journal.pgen.1001227

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Peer-reviewed

Research Article

The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

James F. Theis,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Carmela Irene,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Ann Dershowitz,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Renee L. Brost,

Affiliation Banting & Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
⨯
Michael L. Tobin,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Fabiana M. di Sanzo,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Jian-Ying Wang,

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯
Charles Boone,

Affiliation Banting & Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
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Carol S. Newlon

* E-mail: newlon@umdnj.edu

Affiliation Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
⨯

The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

James F. Theis,
Carmela Irene,
Ann Dershowitz,
Renee L. Brost,
Michael L. Tobin,
Fabiana M. di Sanzo,
Jian-Ying Wang,
Charles Boone,
Carol S. Newlon

Published: December 2, 2010
https://doi.org/10.1371/journal.pgen.1001227

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DNA damage
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