Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A

• Carola Marzi ,

  Contributed equally to this work with: Carola Marzi, Eva Albrecht

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Eva Albrecht ,

  Contributed equally to this work with: Carola Marzi, Eva Albrecht

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Pirro G. Hysi,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Vasiliki Lagou,

  Affiliations Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Melanie Waldenberger,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Anke Tönjes,

  Affiliations Department of Medicine, University of Leipzig, Leipzig, Germany, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany

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• Inga Prokopenko,

  Affiliations Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Katharina Heim,

  Affiliation Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Hannah Blackburn,

  Affiliation Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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• Janina S. Ried,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Marcus E. Kleber,

  Affiliation LURIC, Freiburg, Germany

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• Massimo Mangino,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Barbara Thorand,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Annette Peters,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Christopher J. Hammond,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Harald Grallert,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Bernhard O. Boehm,

  Affiliation Division of Endocrinology, Department of Medicine, University of Ulm, Ulm, Germany

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• Peter Kovacs,

  Affiliation Interdisciplinary Centre for Clinical Research, Department of Internal Medicine III, University of Leipzig, Leipzig, Germany

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• Ludwig Geistlinger,

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Holger Prokisch,

  Affiliations Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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• Bernhard R. Winkelmann,

  Affiliation Cardiology Group Sachsenhausen, Frankfurt, Germany

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• Tim D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• H.-Erich Wichmann,

  Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Grosshadern, Munich, Germany

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• Michael Stumvoll,

  Affiliation Department of Medicine, University of Leipzig, Leipzig, Germany

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• Nicole Soranzo,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute Genome Campus, Hinxton, United Kingdom

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• Winfried März,

  Affiliations SynLab Medizinisches Versorgungszentrum Heidelberg, Eppelheim, Germany, Institut für Public Health, Sozialmedizin und Epidemiologie, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria

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• Wolfgang Koenig,

  Affiliation Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany

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• Thomas Illig ,

  * E-mail: illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

  ¶These authors also contributed equally to this work.

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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•  [ ... ],
• Christian Gieger

  * E-mail: illig@helmholtz-muenchen.de (TI); christian.gieger@helmholtz-muenchen.de (CG)

  ¶These authors also contributed equally to this work.

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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