Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

Anna Aksenova; Kirill Volkov; Jaroslaw Maceluch; Zachary F. Pursell; Igor B. Rogozin; Thomas A. Kunkel; Youri I. Pavlov; Erik Johansson

doi:10.1371/journal.pgen.1001209

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Peer-reviewed

Research Article

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

Anna Aksenova ,

Contributed equally to this work with: Anna Aksenova, Kirill Volkov

Current address: Department of Biology, Tufts University, Medford, Massachusetts, United States of America

Affiliation Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
⨯
Kirill Volkov ,

Contributed equally to this work with: Anna Aksenova, Kirill Volkov

Current address: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Affiliation Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
⨯
Jaroslaw Maceluch,

Affiliation Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
⨯
Zachary F. Pursell,

Current address: Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

Affiliation Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America
⨯
Igor B. Rogozin,

Affiliation National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Thomas A. Kunkel,

Affiliation Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America
⨯
Youri I. Pavlov,

Affiliation Eppley Institute for Research in Cancer, Department of Biochemistry and Molecular Biology, and Department of Microbiology and Pathology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Erik Johansson

* E-mail: erik.johansson@medchem.umu.se

Affiliation Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
⨯

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

Anna Aksenova,
Kirill Volkov,
Jaroslaw Maceluch,
Zachary F. Pursell,
Igor B. Rogozin,
Thomas A. Kunkel,
Youri I. Pavlov,
Erik Johansson

Published: November 18, 2010
https://doi.org/10.1371/journal.pgen.1001209

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Mismatch repair
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DNA replication
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Frameshift mutation
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DNA synthesis
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Polymerases
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Mutagenesis
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Mutation
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DNA polymerase
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