Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

Magda Granata; Federico Lazzaro; Daniele Novarina; Davide Panigada; Fabio Puddu; Carla Manuela Abreu; Ramesh Kumar; Muriel Grenon; Noel F. Lowndes; Paolo Plevani; Marco Muzi-Falconi

doi:10.1371/journal.pgen.1001047

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Peer-reviewed

Research Article

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

Magda Granata ,

Contributed equally to this work with: Magda Granata, Federico Lazzaro

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Federico Lazzaro ,

Contributed equally to this work with: Magda Granata, Federico Lazzaro

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Daniele Novarina,

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Davide Panigada,

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Fabio Puddu,

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Carla Manuela Abreu,

Affiliation Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland
⨯
Ramesh Kumar,

Affiliation Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland
⨯
Muriel Grenon,

Affiliation Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland
⨯
Noel F. Lowndes,

Affiliation Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland
⨯
Paolo Plevani ,

* E-mail: marco.muzifalconi@unimi.it (MM-F); paolo.plevani@unimi.it (PP)

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯
Marco Muzi-Falconi

* E-mail: marco.muzifalconi@unimi.it (MM-F); paolo.plevani@unimi.it (PP)

Affiliation Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
⨯

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

Magda Granata,
Federico Lazzaro,
Daniele Novarina,
Davide Panigada,
Fabio Puddu,
Carla Manuela Abreu,
Ramesh Kumar,
Muriel Grenon,
Noel F. Lowndes,
Paolo Plevani

Published: August 5, 2010
https://doi.org/10.1371/journal.pgen.1001047

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Chromatin
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DNA damage
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Phosphorylation
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Dimerization
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Cell cycle and cell division
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Cell binding
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Protein extraction
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Histones
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