Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

Paola Fabrizio; Shawn Hoon; Mehrnaz Shamalnasab; Abdulaye Galbani; Min Wei; Guri Giaever; Corey Nislow; Valter D. Longo

doi:10.1371/journal.pgen.1001024

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Peer-reviewed

Research Article

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

Paola Fabrizio ,

Contributed equally to this work with: Paola Fabrizio, Shawn Hoon

Affiliations Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America, Laboratoire de Biologie Moléculaire de la Cellule, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France
⨯
Shawn Hoon ,

Contributed equally to this work with: Paola Fabrizio, Shawn Hoon

Affiliation Department of Genetics, Stanford University, Palo Alto, California, United States of America
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Mehrnaz Shamalnasab,

Affiliation Laboratoire de Biologie Moléculaire de la Cellule, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France
⨯
Abdulaye Galbani,

Affiliation Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
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Min Wei,

Affiliation Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
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Guri Giaever,

Affiliations Department of Genetics, Stanford University, Palo Alto, California, United States of America, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Corey Nislow ,

* E-mail: vlongo@usc.edu (VDL); corey.nislow@gmail.com (CN)

Affiliations Department of Genetics, Stanford University, Palo Alto, California, United States of America, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
⨯
Valter D. Longo

* E-mail: vlongo@usc.edu (VDL); corey.nislow@gmail.com (CN)

Affiliation Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
⨯

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

Paola Fabrizio,
Shawn Hoon,
Mehrnaz Shamalnasab,
Abdulaye Galbani,
Min Wei,
Guri Giaever,
Corey Nislow,
Valter D. Longo

Published: July 15, 2010
https://doi.org/10.1371/journal.pgen.1001024

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