An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

• Yi-Hsiang Hsu ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliations Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, United States of America, Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Framingham, Massachusetts, United States of America

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• M. Carola Zillikens ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative, The Hague, The Netherlands

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• Scott G. Wilson ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Departments of Endocrinology, Diabetes, and Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia

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• Charles R. Farber ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliation Department of Medicine, Division of Cardiovascular Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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• Serkalem Demissie,

  Affiliations Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, United States of America

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• Nicole Soranzo,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

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• Estelle N. Bianchi,

  Affiliation Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Geneva Hospital, Geneva, Switzerland

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• Elin Grundberg,

  Affiliations Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, Department of Human Genetics, McGill University, Montreal, Canada, McGill University and Genome Quebec Innovation Center, Montreal, Canada

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• Liming Liang,

  Affiliation Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• J. Brent Richards,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Department of Human Genetics, McGill University, Montreal, Canada, Departments of Medicine, Human Genetics, and Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Canada

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• Karol Estrada,

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative, The Hague, The Netherlands

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• Yanhua Zhou,

  Affiliations Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, United States of America

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• Atila van Nas,

  Affiliation Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Miriam F. Moffatt,

  Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom

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• Guangju Zhai,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Albert Hofman,

  Affiliations Netherlands Genomics Initiative, The Hague, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Joyce B. van Meurs,

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative, The Hague, The Netherlands

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• Huibert A. P. Pols,

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Roger I. Price,

  Affiliation Departments of Endocrinology, Diabetes, and Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia

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• Olle Nilsson,

  Affiliation Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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• Tomi Pastinen,

  Affiliations Department of Human Genetics, McGill University, Montreal, Canada, McGill University and Genome Quebec Innovation Center, Montreal, Canada

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• L. Adrienne Cupples,

  Affiliations Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, United States of America

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• Aldons J. Lusis,

  Affiliation Departments of Medicine, Human Genetics, Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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• Eric E. Schadt,

  Affiliation Rosetta Inpharmatics/Merck, Seattle, Washington, United States of America

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• Serge Ferrari,

  Affiliation Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Geneva Hospital, Geneva, Switzerland

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• André G. Uitterlinden,

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative, The Hague, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Fernando Rivadeneira ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliations Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Netherlands Genomics Initiative, The Hague, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

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• Timothy D. Spector ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• David Karasik ,

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  * E-mail: kiel@hrca.harvard.edu (DPK); karasik@hrca.harvard.edu (DK)

  Affiliations Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, United States of America, Framingham Heart Study, Framingham, Massachusetts, United States of America

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•  [ ... ],
• Douglas P. Kiel

  Contributed equally to this work with: Yi-Hsiang Hsu, M. Carola Zillikens, Scott G. Wilson, Charles R. Farber, Fernando Rivadeneira, Timothy D. Spector, David Karasik, Douglas P. Kiel

  * E-mail: kiel@hrca.harvard.edu (DPK); karasik@hrca.harvard.edu (DK)

  Affiliations Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, Massachusetts, United States of America, Framingham Heart Study, Framingham, Massachusetts, United States of America

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