Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

Dirk Bäumer; Sheena Lee; George Nicholson; Joanna L. Davies; Nicholas J. Parkinson; Lyndsay M. Murray; Thomas H. Gillingwater; Olaf Ansorge; Kay E. Davies; Kevin Talbot

doi:10.1371/journal.pgen.1000773

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Open Access

Peer-reviewed

Research Article

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

Dirk Bäumer,

Affiliation MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Sheena Lee,

Affiliation MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
George Nicholson,

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Joanna L. Davies,

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom
⨯
Nicholas J. Parkinson,

Affiliation MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Lyndsay M. Murray,

Affiliation Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh, United Kingdom
⨯
Thomas H. Gillingwater,

Affiliation Centre for Integrative Physiology and Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh Medical School, Edinburgh, United Kingdom
⨯
Olaf Ansorge,

Affiliation Department of Neuropathology, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Kay E. Davies,

Affiliation MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Kevin Talbot

* E-mail: kevin.talbot@clneuro.ox.ac.uk

Affiliations MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
⨯

Alternative Splicing Events Are a Late Feature of Pathology in a Mouse Model of Spinal Muscular Atrophy

Dirk Bäumer,
Sheena Lee,
George Nicholson,
Joanna L. Davies,
Nicholas J. Parkinson,
Lyndsay M. Murray,
Thomas H. Gillingwater,
Olaf Ansorge,
Kay E. Davies,
Kevin Talbot

Published: December 18, 2009
https://doi.org/10.1371/journal.pgen.1000773

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Spinal cord
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Gene expression
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Alternative splicing
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