New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

• Liqin Cao ,

  Contributed equally to this work with: Liqin Cao, Hiroshi Shitara

  Affiliations Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan, Technology and Development Team for Mammalian Cellular Dynamics, BioResource Center (BRC) RIKEN Tsukuba Institute, Ibaraki, Japan

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• Hiroshi Shitara ,

  Contributed equally to this work with: Liqin Cao, Hiroshi Shitara

  * E-mail: shitara-hr@igakuken.or.jp

  Affiliation Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan

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• Michihiko Sugimoto,

  Affiliation Technology and Development Team for Mammalian Cellular Dynamics, BioResource Center (BRC) RIKEN Tsukuba Institute, Ibaraki, Japan

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• Jun-Ichi Hayashi,

  Affiliation Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan

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• Kuniya Abe,

  Affiliation Technology and Development Team for Mammalian Cellular Dynamics, BioResource Center (BRC) RIKEN Tsukuba Institute, Ibaraki, Japan

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• Hiromichi Yonekawa

  Affiliation Laboratory of Mouse Models for Human Heritable Diseases, The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan

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