Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus

Raffaella Nativio; Kerstin S. Wendt; Yoko Ito; Joanna E. Huddleston; Santiago Uribe-Lewis; Kathryn Woodfine; Christel Krueger; Wolf Reik; Jan-Michael Peters; Adele Murrell

doi:10.1371/journal.pgen.1000739

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Open Access

Peer-reviewed

Research Article

Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus

Raffaella Nativio ,

Contributed equally to this work with: Raffaella Nativio, Kerstin S. Wendt

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯
Kerstin S. Wendt ,

Contributed equally to this work with: Raffaella Nativio, Kerstin S. Wendt

Current address: Department of Cell Biology and Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands

Affiliation Institute of Molecular Pathology, Vienna, Austria
⨯
Yoko Ito,

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯
Joanna E. Huddleston,

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯
Santiago Uribe-Lewis,

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯
Kathryn Woodfine,

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯
Christel Krueger,

Affiliation Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
⨯
Wolf Reik,

Affiliations Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
⨯
Jan-Michael Peters ,

* E-mail: Jan-Michael.Peters@imp.ac.at (J-MP); amm207@cam.ac.uk (AM)

¶These authors are joint senior authors on this work.

Affiliation Institute of Molecular Pathology, Vienna, Austria
⨯
Adele Murrell

* E-mail: Jan-Michael.Peters@imp.ac.at (J-MP); amm207@cam.ac.uk (AM)

¶These authors are joint senior authors on this work.

Affiliation Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
⨯

Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus

Raffaella Nativio,
Kerstin S. Wendt,
Yoko Ito,
Joanna E. Huddleston,
Santiago Uribe-Lewis,
Kathryn Woodfine,
Christel Krueger,
Wolf Reik,
Jan-Michael Peters,
Adele Murrell

Published: November 26, 2009
https://doi.org/10.1371/journal.pgen.1000739

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Genetic loci
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DNA methylation
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