Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

M. Helen Rajpar; Ben McDermott; Louise Kung; Rachel Eardley; Lynette Knowles; Mel Heeran; David J. Thornton; Richard Wilson; John F. Bateman; Richard Poulsom; Peter Arvan; Karl E. Kadler; Michael D. Briggs; Raymond P. Boot-Handford

doi:10.1371/journal.pgen.1000691

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Open Access

Peer-reviewed

Research Article

Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

M. Helen Rajpar,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Ben McDermott,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Louise Kung,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Rachel Eardley,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Lynette Knowles,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Mel Heeran,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
David J. Thornton,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Richard Wilson,

Affiliation Musculoskeletal Disorders Theme, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
⨯
John F. Bateman,

Affiliation Musculoskeletal Disorders Theme, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
⨯
Richard Poulsom,

Affiliation Histopathology Unit, Cancer Research UK, London Research Institute, London, United Kingdom
⨯
Peter Arvan,

Affiliation Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Karl E. Kadler,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Michael D. Briggs,

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Raymond P. Boot-Handford

* E-mail: ray.boot-handford@manchester.ac.uk

Affiliation Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯

Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

M. Helen Rajpar,
Ben McDermott,
Louise Kung,
Rachel Eardley,
Lynette Knowles,
Mel Heeran,
David J. Thornton,
Richard Wilson,
John F. Bateman,
Richard Poulsom

Published: October 16, 2009
https://doi.org/10.1371/journal.pgen.1000691

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