Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging

Heather E. Wheeler; E. Jeffrey Metter; Toshiko Tanaka; Devin Absher; John Higgins; Jacob M. Zahn; Julie Wilhelmy; Ronald W. Davis; Andrew Singleton; Richard M. Myers; Luigi Ferrucci; Stuart K. Kim

doi:10.1371/journal.pgen.1000685

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Peer-reviewed

Research Article

Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging

Heather E. Wheeler,

Affiliation Department of Genetics, Stanford University Medical Center, Stanford, California, United States of America
⨯
E. Jeffrey Metter,

Affiliations Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America, Medstar Research Institute, Baltimore, Maryland, United States of America
⨯
Toshiko Tanaka,

Affiliations Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America, Medstar Research Institute, Baltimore, Maryland, United States of America
⨯
Devin Absher,

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
⨯
John Higgins,

Affiliation Department of Pathology, Stanford University Medical Center, Stanford, California, United States of America
⨯
Jacob M. Zahn,

Affiliation Stanford Genome Technology Center, Palo Alto, California, United States of America
⨯
Julie Wilhelmy,

Affiliation Stanford Genome Technology Center, Palo Alto, California, United States of America
⨯
Ronald W. Davis,

Affiliation Stanford Genome Technology Center, Palo Alto, California, United States of America
⨯
Andrew Singleton,

Affiliation Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America
⨯
Richard M. Myers,

Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
⨯
Luigi Ferrucci,

Affiliations Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America, Medstar Research Institute, Baltimore, Maryland, United States of America
⨯
Stuart K. Kim

* E-mail: kim@cmgm.stanford.edu

Affiliations Department of Genetics, Stanford University Medical Center, Stanford, California, United States of America, Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America
⨯

Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging

Heather E. Wheeler,
E. Jeffrey Metter,
Toshiko Tanaka,
Devin Absher,
John Higgins,
Jacob M. Zahn,
Julie Wilhelmy,
Ronald W. Davis,
Andrew Singleton,
Richard M. Myers

Published: October 16, 2009
https://doi.org/10.1371/journal.pgen.1000685

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01 Sep 2011
15:27 GMT
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Is MMP20 Really Expressed in the Kidney? Posted by jbart on 12 Aug 2011 at 15:45 GMT

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Single nucleotide polymorphisms
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Kidneys
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Aging
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Heterozygosity
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Creatinine
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Gene expression
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Variant genotypes
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