Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

Charlene M. Downey; Chelsea R. Horton; Bradley A. Carlson; Trish E. Parsons; Dolph L. Hatfield; Benedikt Hallgrímsson; Frank R. Jirik

doi:10.1371/journal.pgen.1000616

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Peer-reviewed

Research Article

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

Charlene M. Downey,

Affiliations The McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Chelsea R. Horton,

Affiliations The McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯
Bradley A. Carlson,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Trish E. Parsons,

Affiliations The McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada
⨯
Dolph L. Hatfield,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Benedikt Hallgrímsson,

Affiliations The McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada, Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada
⨯
Frank R. Jirik

* E-mail: jirik@ucalgary.ca

Affiliations The McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
⨯

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck Disease

Charlene M. Downey,
Chelsea R. Horton,
Bradley A. Carlson,
Trish E. Parsons,
Dolph L. Hatfield,
Benedikt Hallgrímsson,
Frank R. Jirik

Published: August 21, 2009
https://doi.org/10.1371/journal.pgen.1000616

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Micronutrient deficiencies
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Selenium
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Cartilage
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