EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

Gyungah Jun; Hong Guo; Barbara E. K. Klein; Ronald Klein; Jie Jin Wang; Paul Mitchell; Hui Miao; Kristine E. Lee; Tripti Joshi; Matthias Buck; Preeti Chugha; David Bardenstein; Alison P. Klein; Joan E. Bailey-Wilson; Xiaohua Gong; Tim D. Spector; Toby Andrew; Christopher J. Hammond; Robert C. Elston; Sudha K. Iyengar; Bingcheng Wang

doi:10.1371/journal.pgen.1000584

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Peer-reviewed

Research Article

EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

Gyungah Jun ,

Contributed equally to this work with: Gyungah Jun, Hong Guo

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Hong Guo ,

Contributed equally to this work with: Gyungah Jun, Hong Guo

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Barbara E. K. Klein,

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Ronald Klein,

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Jie Jin Wang,

Affiliations Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Department of Ophthalmology, University of Sydney, Sydney, Australia, Centre for Eye Research Australia and Department of Ophthalmology, University of Melbourne, Melbourne, Australia
⨯
Paul Mitchell,

Affiliation Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Department of Ophthalmology, University of Sydney, Sydney, Australia
⨯
Hui Miao,

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Kristine E. Lee,

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Tripti Joshi,

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Matthias Buck,

Affiliation Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Preeti Chugha,

Affiliation Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
David Bardenstein,

Affiliation Ocular Oncology Service, Department of Ophthalmology and Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Alison P. Klein,

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Joan E. Bailey-Wilson,

Affiliation Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Xiaohua Gong,

Affiliation School of Optometry and Vision Science Program, University of California Berkeley/University of California San Francisco Joint Bioengineering Graduate Program, University of California Berkeley, Berkeley, California, United States of America
⨯
Tim D. Spector,

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom
⨯
Toby Andrew,

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom
⨯
Christopher J. Hammond,

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom
⨯
Robert C. Elston,

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
Sudha K. Iyengar ,

* E-mail: ski@case.edu (SKI); bxw14@case.edu (BW)

Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
[ ... ],
Bingcheng Wang

* E-mail: ski@case.edu (SKI); bxw14@case.edu (BW)

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
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EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans

Gyungah Jun,
Hong Guo,
Barbara E. K. Klein,
Ronald Klein,
Jie Jin Wang,
Paul Mitchell,
Hui Miao,
Kristine E. Lee,
Tripti Joshi,
Matthias Buck

Published: July 31, 2009
https://doi.org/10.1371/journal.pgen.1000584

Reader Comments (2)

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25 Sep 2009
19:19 GMT
Most Recent

The EPHA2 Gene is Associated with Cataracts Linked to Chromosome 1p Posted by ashiels on 25 Sep 2009 at 19:19 GMT
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31 Jul 2009
05:46 GMT
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Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract Posted by xuezhangpumc on 31 Jul 2009 at 05:46 GMT

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