The Ups and Downs of Mutation Frequencies during Aging Can Account for the Apert Syndrome Paternal Age Effect

• Song-Ro Yoon,

  Affiliation Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America

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• Jian Qin,

  Current address: Fluidigm Corporation, South San Francisco, California, United States of America

  Affiliation Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America

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• Rivka L. Glaser,

  Affiliation Department of Biology, Stevenson University, Stevenson, Maryland, United States of America

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• Ethylin Wang Jabs,

  Affiliation Departments of Genetics and Genomic Sciences, Pediatrics, and Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America

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• Nancy S. Wexler,

  Affiliations Departments of Neurology and Psychiatry, Columbia University Medical Center, New York, New York, United States of America, Hereditary Disease Foundation, New York, New York, United States of America

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• Rebecca Sokol,

  Affiliation Department of Obstetrics and Gynecology and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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• Norman Arnheim,

  Affiliation Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America

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• Peter Calabrese

  * E-mail: petercal@usc.edu

  Affiliation Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, United States of America

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