Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

Utpal P. Davé; Keiko Akagi; Rati Tripathi; Susan M. Cleveland; Mary A. Thompson; Ming Yi; Robert Stephens; James R. Downing; Nancy A. Jenkins; Neal G. Copeland

doi:10.1371/journal.pgen.1000491

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Open Access

Peer-reviewed

Research Article

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

Utpal P. Davé ,

* E-mail: utpal.dave@vanderbilt.edu

Affiliations Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Keiko Akagi,

Affiliation Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Rati Tripathi,

Affiliations Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Susan M. Cleveland,

Affiliations Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Mary A. Thompson,

Affiliation Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Ming Yi,

Affiliation Advanced Biomedical Computing Center, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Robert Stephens,

Affiliation Advanced Biomedical Computing Center, National Cancer Institute, Frederick, Maryland, United States of America
⨯
James R. Downing,

Affiliation St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Nancy A. Jenkins,

Affiliation Institute of Molecular and Cell Biology, Biopolis, Singapore, Singapore
⨯
Neal G. Copeland

Affiliation Institute of Molecular and Cell Biology, Biopolis, Singapore, Singapore
⨯

Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

Utpal P. Davé,
Keiko Akagi,
Rati Tripathi,
Susan M. Cleveland,
Mary A. Thompson,
Ming Yi,
Robert Stephens,
James R. Downing,
Nancy A. Jenkins,
Neal G. Copeland

Published: May 22, 2009
https://doi.org/10.1371/journal.pgen.1000491

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Insertion mutation
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Gene disruption
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