Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Sarit Suissa; Zhibo Wang; Jason Poole; Sharine Wittkopp; Jeanette Feder; Timothy E. Shutt; Douglas C. Wallace; Gerald S. Shadel; Dan Mishmar

doi:10.1371/journal.pgen.1000474

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Peer-reviewed

Research Article

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Sarit Suissa,

Affiliation Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯
Zhibo Wang,

Affiliation Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Jason Poole,

Affiliations The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America, Nanogen, Inc., San Diego, California, United States of America
⨯
Sharine Wittkopp,

Affiliation The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America
⨯
Jeanette Feder,

Affiliation Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯
Timothy E. Shutt,

Affiliation Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Douglas C. Wallace,

Affiliation The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America
⨯
Gerald S. Shadel,

Affiliation Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Dan Mishmar

* E-mail: dmishmar@bgu.ac.il

Affiliation Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

Sarit Suissa,
Zhibo Wang,
Jason Poole,
Sharine Wittkopp,
Jeanette Feder,
Timothy E. Shutt,
Douglas C. Wallace,
Gerald S. Shadel,
Dan Mishmar

Published: May 8, 2009
https://doi.org/10.1371/journal.pgen.1000474

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Mitochondrial DNA
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Haplogroups
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Point mutation
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