Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels

Open Access

Peer-reviewed

Research Article

Shondra M. Pruett-Miller,

Affiliations Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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David W. Reading,

Affiliations Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Shaina N. Porter,

Affiliations Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Matthew H. Porteus

* E-mail: matthew.porteus@utsouthwestern.edu

Affiliations Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Gene targeting
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Transfection
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Toxicity
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Zinc finger nucleases
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Cytotoxicity assay
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DNA
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Nucleases
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Gene regulation
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