Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

Open Access

Peer-reviewed

Research Article

Shamil R. Sunyaev ,

Contributed equally to this work with: Shamil R. Sunyaev, Alexey Lugovskoy

* E-mail: sunyaev@rics.bwh.harvard.edu (SRS); leonid.gorelik@biogenidec.com (LG)

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alexey Lugovskoy ,

Contributed equally to this work with: Shamil R. Sunyaev, Alexey Lugovskoy

Affiliation Departments of Drug Discovery, Biogen IDEC, Cambridge, Massachusetts, United States of America
⨯
Kenneth Simon,

Affiliation Departments of Drug Discovery, Biogen IDEC, Cambridge, Massachusetts, United States of America
⨯
Leonid Gorelik

* E-mail: sunyaev@rics.bwh.harvard.edu (SRS); leonid.gorelik@biogenidec.com (LG)

Affiliation Department of Neurobiology, Biogen IDEC, Cambridge, Massachusetts, United States of America
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JC virus
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Microbial mutation
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Sialic acids
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Hemagglutination
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Viral evolution
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Phylogenetic analysis
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Kidneys
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Protein sequencing
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