Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

• Makoto Nakahara,

  Current address: Research and Development Department, Transgenic Inc., 7-1-14 Minatojimaminami-machi, Chuo-ku, Kobe, Japan

  Affiliations CREST Research Project, Japan Science and Technology Agency, Saitama, Japan, Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Eiichiro Sonoda,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Kuniharu Nojima,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Julian E. Sale,

  Affiliation Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, United Kingdom

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• Katsuya Takenaka,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Koji Kikuchi,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Yoshihito Taniguchi,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Kyoko Nakamura,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Yoshiki Sumitomo,

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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• Ronan T. Bree,

  Affiliations Genome Stability Laboratory, Department of Biochemistry, National University of Ireland-Galway, Galway, Ireland, National Centre for Biomedical Engineering Science, National University of Ireland-Galway, Galway, Ireland

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• Noel F. Lowndes,

  Affiliations Genome Stability Laboratory, Department of Biochemistry, National University of Ireland-Galway, Galway, Ireland, National Centre for Biomedical Engineering Science, National University of Ireland-Galway, Galway, Ireland

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• Shunichi Takeda

  * E-mail: stakeda@rg.med.kyoto-u.ac.jp

  Affiliation CREST Research Project, Japan Science and Technology Agency, Saitama, Japan

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