Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells

• Lisa Yu ,

  Contributed equally to this work with: Lisa Yu, Andres Lopez

  Affiliations Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

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• Andres Lopez ,

  Contributed equally to this work with: Lisa Yu, Andres Lopez

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Abderrahmane Anaflous,

  Affiliation Laboratoire de Chimie du Solide Minéral et Analytique, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

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• Brahim El Bali,

  Affiliation Laboratoire de Chimie du Solide Minéral et Analytique, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

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• Abdellah Hamal,

  Affiliation Laboratoire de Génétique et Biotechnologies, Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

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• Elke Ericson,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Lawrence E. Heisler,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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• Angus McQuibban,

  Affiliation Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Guri Giaever,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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• Corey Nislow,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Charles Boone,

  Affiliations Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Grant W. Brown ,

  * E-mail: grant.brown@utoronto.ca (GWB); bmbellaoui@gmail.com (MB)

  Affiliations Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

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• Mohammed Bellaoui

  * E-mail: grant.brown@utoronto.ca (GWB); bmbellaoui@gmail.com (MB)

  Affiliations Laboratoire de Génétique et Biotechnologies, Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco, Faculté Pluridisciplinaire de Nador, Université Mohamed Premier, Nador, Morocco

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