Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection

• Steffen Schmidt ,

  Contributed equally to this work with: Steffen Schmidt, Anna Gerasimova

  Affiliations Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen, Germany

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• Anna Gerasimova ,

  Contributed equally to this work with: Steffen Schmidt, Anna Gerasimova

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Fyodor A. Kondrashov,

  Affiliation Section on Ecology, Behavior, and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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• Ivan A. Adzuhbei,

  Affiliation Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Alexey S. Kondrashov ,

  * E-mail: kondrash@umich.edu (ASK); ssunyaev@rics.bwh.harvard.edu (SS)

  Affiliations Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Shamil Sunyaev

  * E-mail: kondrash@umich.edu (ASK); ssunyaev@rics.bwh.harvard.edu (SS)

  Affiliation Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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