AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

Alessandro Gardini; Matteo Cesaroni; Lucilla Luzi; Akiko J. Okumura; Joseph R. Biggs; Simone P. Minardi; Elisa Venturini; Dong-Er Zhang; Pier Giuseppe Pelicci; Myriam Alcalay

doi:10.1371/journal.pgen.1000275

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Open Access

Peer-reviewed

Research Article

AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

Alessandro Gardini,

Affiliation Department of Experimental Oncology, IEO–European Institute of Oncology, Milan, Italy
⨯
Matteo Cesaroni,

Affiliation Department of Experimental Oncology, IEO–European Institute of Oncology, Milan, Italy
⨯
Lucilla Luzi,

Affiliation IFOM–FIRC Institute for Molecular Oncology Foundation, Milan, Italy
⨯
Akiko J. Okumura,

Affiliation Moores UCSD Cancer Center, Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
⨯
Joseph R. Biggs,

Affiliation Moores UCSD Cancer Center, Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
⨯
Simone P. Minardi,

Affiliations IFOM–FIRC Institute for Molecular Oncology Foundation, Milan, Italy, Cogentech–Consortium for Genomic Technologies, Milan, Italy
⨯
Elisa Venturini,

Affiliation Cogentech–Consortium for Genomic Technologies, Milan, Italy
⨯
Dong-Er Zhang,

Affiliation Moores UCSD Cancer Center, Department of Pathology and Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
⨯
Pier Giuseppe Pelicci,

Affiliations Department of Experimental Oncology, IEO–European Institute of Oncology, Milan, Italy, Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Milan, Italy
⨯
Myriam Alcalay

* E-mail: myriam.alcalay@ifom-ieo-campus.it

Affiliations Department of Experimental Oncology, IEO–European Institute of Oncology, Milan, Italy, Cogentech–Consortium for Genomic Technologies, Milan, Italy, Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Milan, Italy
⨯

AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

Alessandro Gardini,
Matteo Cesaroni,
Lucilla Luzi,
Akiko J. Okumura,
Joseph R. Biggs,
Simone P. Minardi,
Elisa Venturini,
Dong-Er Zhang,
Pier Giuseppe Pelicci,
Myriam Alcalay

Published: November 28, 2008
https://doi.org/10.1371/journal.pgen.1000275

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Transcription factors
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Binding analysis
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Gene expression
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Gene regulation
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Acute myeloid leukemia
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