Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

Caleb Gonzalez; Lilach Hadany; Rebecca G. Ponder; Mellanie Price; P. J. Hastings; Susan M. Rosenberg

doi:10.1371/journal.pgen.1000208

Loading metrics

Open Access

Peer-reviewed

Research Article

Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

Caleb Gonzalez,

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lilach Hadany ,

Contributed equally to this work with: Lilach Hadany, Rebecca G. Ponder

Current address: Department of Plant Science, Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel

Affiliation Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Rebecca G. Ponder ,

Contributed equally to this work with: Lilach Hadany, Rebecca G. Ponder

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mellanie Price,

Current address: Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
P. J. Hastings,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Susan M. Rosenberg

* E-mail: smr@bcm.edu

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

Caleb Gonzalez,
Lilach Hadany,
Rebecca G. Ponder,
Mellanie Price,
P. J. Hastings,
Susan M. Rosenberg

Published: October 3, 2008
https://doi.org/10.1371/journal.pgen.1000208

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mutagenesis
Is the Subject Area "Mutagenesis" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Cellular stress responses
Is the Subject Area "Cellular stress responses" applicable to this article?

Thanks for your feedback.
Frameshift mutation
Is the Subject Area "Frameshift mutation" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Bacterial genomics
Is the Subject Area "Bacterial genomics" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.