Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2

Carlos F. Pereira; Rémi Terranova; Natalie K. Ryan; Joana Santos; Kelly J. Morris; Wei Cui; Matthias Merkenschlager; Amanda G. Fisher

doi:10.1371/journal.pgen.1000170

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Peer-reviewed

Research Article

Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2

Carlos F. Pereira,

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Rémi Terranova,

Current address: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Natalie K. Ryan,

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Joana Santos,

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Kelly J. Morris,

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Wei Cui,

Affiliation Stem Cell Initiative, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
⨯
Matthias Merkenschlager,

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Amanda G. Fisher

* E-mail: amanda.fisher@csc.mrc.ac.uk

Affiliation Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯

Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2

Carlos F. Pereira,
Rémi Terranova,
Natalie K. Ryan,
Joana Santos,
Kelly J. Morris,
Wei Cui,
Matthias Merkenschlager,
Amanda G. Fisher

Published: September 5, 2008
https://doi.org/10.1371/journal.pgen.1000170

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Cell fusion
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B cells
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Gene expression
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DNA methylation
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Cell differentiation
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DAPI staining
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