An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection

Yanis A. Boumber; Yutaka Kondo; Xuqi Chen; Lanlan Shen; Yi Guo; Carmen Tellez; Marcos R. H. Estécio; Saira Ahmed; Jean-Pierre J. Issa

doi:10.1371/journal.pgen.1000162

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Open Access

Peer-reviewed

Research Article

An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection

Yanis A. Boumber,

Affiliations Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America, Program in Cancer Biology, Graduate School of Biomedical Sciences, University of Texas, Houston, Texas, United States of America
⨯
Yutaka Kondo,

Current address: Division of Molecular Oncology, Aichi Cancer Center, 1-1 Kanakoden, Chikusa-ku, Nagoya 464-8681, Japan

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Xuqi Chen,

Current address: Department of Physiological Science, University of California at Los Angeles, LSB 4117, 621 Charles E. Young South, Los Angeles, CA 90095-1606

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Lanlan Shen,

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Yi Guo,

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Carmen Tellez,

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Marcos R. H. Estécio,

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Saira Ahmed,

Affiliation Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
⨯
Jean-Pierre J. Issa

* E-mail: jpissa@mdanderson.org

Affiliations Department of Leukemia, M. D. Anderson Cancer Center, University of Texas, Houston, Texas, United States of America, Program in Cancer Biology, Graduate School of Biomedical Sciences, University of Texas, Houston, Texas, United States of America
⨯

An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection

Yanis A. Boumber,
Yutaka Kondo,
Xuqi Chen,
Lanlan Shen,
Yi Guo,
Carmen Tellez,
Marcos R. H. Estécio,
Saira Ahmed,
Jean-Pierre J. Issa

Published: August 22, 2008
https://doi.org/10.1371/journal.pgen.1000162

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DNA methylation
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Homozygosity
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Methylation
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Polymerase chain reaction
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Cancers and neoplasms
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