Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

• Adam R. Boyko,

  Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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• Scott H. Williamson,

  Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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• Amit R. Indap,

  Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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• Jeremiah D. Degenhardt,

  Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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• Ryan D. Hernandez,

  Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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• Kirk E. Lohmueller,

  Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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• Mark D. Adams,

  Affiliation Department of Genetics, BRB-624, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Steffen Schmidt,

  Affiliation Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• John J. Sninsky,

  Affiliation Celera Diagnostics, Alameda, California, United States of America

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• Shamil R. Sunyaev,

  Affiliation Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Thomas J. White,

  Affiliation Celera Diagnostics, Alameda, California, United States of America

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• Rasmus Nielsen,

  Affiliation Center for Comparative Genomics, University of Copenhagen, Copenhagen, Denmark

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• Andrew G. Clark,

  Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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• Carlos D. Bustamante

  * E-mail: cdb28@cornell.edu

  Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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