Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators

Chunlei Wu; David L. Delano; Nico Mitro; Stephen V. Su; Jeff Janes; Phillip McClurg; Serge Batalov; Genevieve L. Welch; Jie Zhang; Anthony P. Orth; John R. Walker; Richard J. Glynne; Michael P. Cooke; Joseph S. Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Enrique Saez; Tim Wiltshire; Andrew I. Su

doi:10.1371/journal.pgen.1000070

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Open Access

Peer-reviewed

Research Article

Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators

Chunlei Wu,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
David L. Delano,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Nico Mitro,

Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Stephen V. Su,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Jeff Janes,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Phillip McClurg,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Serge Batalov,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Genevieve L. Welch,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Jie Zhang,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Anthony P. Orth,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
John R. Walker,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Richard J. Glynne,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Michael P. Cooke,

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
Joseph S. Takahashi,

Affiliations Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America
⨯
Kazuhiro Shimomura,

Affiliations Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America
⨯
Akira Kohsaka,

Affiliations Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America
⨯
Joseph Bass,

Affiliations Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, United States of America, Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, United States of America
⨯
Enrique Saez,

Affiliation Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Tim Wiltshire,

Current address: School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
[ ... ],
Andrew I. Su

* E-mail: asu@gnf.org

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America
⨯
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Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators

Chunlei Wu,
David L. Delano,
Nico Mitro,
Stephen V. Su,
Jeff Janes,
Phillip McClurg,
Serge Batalov,
Genevieve L. Welch,
Jie Zhang,
Anthony P. Orth

Published: May 9, 2008
https://doi.org/10.1371/journal.pgen.1000070

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20 Mar 2009
10:16 GMT
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Link to a related article Posted by PLOS_Genetics on 20 Mar 2009 at 10:16 GMT
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10 Jun 2008
16:32 GMT
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Publisher's Note: Correction to Figure 2B Posted by PLOS_Genetics on 10 Jun 2008 at 16:32 GMT

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Gene expression
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Oxidative phosphorylation
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Regulator genes
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Genetic loci
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Mitochondria
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Gene regulation
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Dehydrogenases
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Small interfering RNA
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