β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

Alla Buzina; Mandy Y. M. Lo; Angela Moffett; Akitsu Hotta; Eden Fussner; Rikki R. Bharadwaj; Peter Pasceri; J. Victor Garcia-Martinez; David P. Bazett-Jones; James Ellis

doi:10.1371/journal.pgen.1000051

Loading metrics

Open Access

Peer-reviewed

Research Article

β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

Alla Buzina ,

Contributed equally to this work with: Alla Buzina, Mandy Y. M. Lo, Angela Moffett

Affiliation Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada
⨯
Mandy Y. M. Lo ,

Contributed equally to this work with: Alla Buzina, Mandy Y. M. Lo, Angela Moffett

Affiliations Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
⨯
Angela Moffett ,

Contributed equally to this work with: Alla Buzina, Mandy Y. M. Lo, Angela Moffett

Affiliations Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
⨯
Akitsu Hotta,

Affiliation Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada
⨯
Eden Fussner,

Affiliations Program in Genetics and Genome Biology, SickKids, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
⨯
Rikki R. Bharadwaj,

Affiliation Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada
⨯
Peter Pasceri,

Affiliation Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada
⨯
J. Victor Garcia-Martinez,

Affiliation Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
David P. Bazett-Jones,

Affiliations Program in Genetics and Genome Biology, SickKids, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
⨯
James Ellis

* E-mail: jellis@sickkids.ca

Affiliations Developmental and Stem Cell Biology Program, SickKids, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
⨯

β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

Alla Buzina,
Mandy Y. M. Lo,
Angela Moffett,
Akitsu Hotta,
Eden Fussner,
Rikki R. Bharadwaj,
Peter Pasceri,
J. Victor Garcia-Martinez,
David P. Bazett-Jones,
James Ellis

Published: April 18, 2008
https://doi.org/10.1371/journal.pgen.1000051

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Introns
Is the Subject Area "Introns" applicable to this article?

Thanks for your feedback.
Lentivirus
Is the Subject Area "Lentivirus" applicable to this article?

Thanks for your feedback.
Chromatin
Is the Subject Area "Chromatin" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Heterochromatin
Is the Subject Area "Heterochromatin" applicable to this article?

Thanks for your feedback.
Gene therapy
Is the Subject Area "Gene therapy" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.