Population Bottlenecks as a Potential Major Shaping Force of Human Genome Architecture

• Adrian Gherman ,

  Contributed equally to this work with: Adrian Gherman, Peter E Chen

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Peter E Chen ,

  Contributed equally to this work with: Adrian Gherman, Peter E Chen

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Tanya M Teslovich,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Pawel Stankiewicz,

  Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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• Marjorie Withers,

  Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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• Carl S Kashuk,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Aravinda Chakravarti,

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• James R Lupski,

  Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America , Texas Children's Hospital, Houston, Texas, United States of America

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• David J Cutler ,

  *To whom correspondence should be addressed. E-mail: dcutler@jhmi.edu (DJC); katsanis@jhmi.edu (NK)

  Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Nicholas Katsanis

  *To whom correspondence should be addressed. E-mail: dcutler@jhmi.edu (DJC); katsanis@jhmi.edu (NK)

  Affiliations McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America , Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America

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