Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Angelo Scuteri; Serena Sanna; Wei-Min Chen; Manuela Uda; Giuseppe Albai; James Strait; Samer Najjar; Ramaiah Nagaraja; Marco Orrú; Gianluca Usala; Mariano Dei; Sandra Lai; Andrea Maschio; Fabio Busonero; Antonella Mulas; Georg B Ehret; Ashley A Fink; Alan B Weder; Richard S Cooper; Pilar Galan; Aravinda Chakravarti; David Schlessinger; Antonio Cao; Edward Lakatta; Gonçalo R Abecasis

doi:10.1371/journal.pgen.0030115

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Peer-reviewed

Research Article

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Angelo Scuteri ,

Contributed equally to this work with: Angelo Scuteri, Serena Sanna

Affiliations Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy , Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Serena Sanna ,

Contributed equally to this work with: Angelo Scuteri, Serena Sanna

Affiliations Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America , Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Wei-Min Chen,

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
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Manuela Uda,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Giuseppe Albai,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
James Strait,

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
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Samer Najjar,

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Ramaiah Nagaraja,

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Marco Orrú,

Affiliations Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy , Unità Operativa Semplice Cardiologia, Divisione di Medicina, Presidio Ospedaliero Santa Barbara, Iglesias, Italy
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Gianluca Usala,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
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Mariano Dei,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Sandra Lai,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Andrea Maschio,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Fabio Busonero,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Antonella Mulas,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Georg B Ehret,

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Ashley A Fink,

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Alan B Weder,

Affiliation Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
⨯
Richard S Cooper,

Affiliation Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Chicago, Illinois, United States of America
⨯
Pilar Galan,

Affiliations Institut Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France , INSERM, U557 (UMR INSERM/INRA/CNAM), Paris, France
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Aravinda Chakravarti,

Affiliation Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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David Schlessinger ,

*To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Antonio Cao,

Affiliation Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
⨯
Edward Lakatta,

Affiliation Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
[ ... ],
Gonçalo R Abecasis

*To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
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Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

Angelo Scuteri,
Serena Sanna,
Wei-Min Chen,
Manuela Uda,
Giuseppe Albai,
James Strait,
Samer Najjar,
Ramaiah Nagaraja,
Marco Orrú,
Gianluca Usala

Published: July 20, 2007
https://doi.org/10.1371/journal.pgen.0030115

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26 Feb 2008
13:58 GMT
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Single nucleotide polymorphisms
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