Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

Kevin Pruitt; Rebekah L Zinn; Joyce E Ohm; Kelly M McGarvey; Sung-Hae L Kang; D. Neil Watkins; James G Herman; Stephen B Baylin

doi:10.1371/journal.pgen.0020040

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Open Access

Peer-reviewed

Research Article

Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

Kevin Pruitt,

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Rebekah L Zinn,

Affiliations The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America , The Graduate Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Joyce E Ohm,

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Kelly M McGarvey,

Affiliations The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America , The Graduate Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sung-Hae L Kang,

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
D. Neil Watkins,

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
James G Herman,

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯
Stephen B Baylin

*To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu

Affiliation The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
⨯

Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

Kevin Pruitt,
Rebekah L Zinn,
Joyce E Ohm,
Kelly M McGarvey,
Sung-Hae L Kang,
D. Neil Watkins,
James G Herman,
Stephen B Baylin

Published: March 31, 2006
https://doi.org/10.1371/journal.pgen.0020040

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DNA methylation
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Breast cancer
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DNA
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Colorectal cancer
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Tumor suppressor genes
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RNA interference
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Reverse transcriptase-polymerase chain reaction
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Gene expression
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