Genetic Analysis of Completely Sequenced Disease-Associated MHC Haplotypes Identifies Shuffling of Segments in Recent Human History

• James A Traherne ,

  Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

  Affiliation Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

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• Roger Horton ,

  Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Anne N Roberts ,

  Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

  Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, United Kingdom

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• Marcos M Miretti ,

  Contributed equally to this work with: James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Matthew E Hurles,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• C. Andrew Stewart,

  Affiliation Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

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• Jennifer L Ashurst,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Alexey M Atrazhev,

  Affiliation Alberta Diabetes Institute (ADI), Department of Medical Microbiology and Immunology, Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Canada

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• Penny Coggill,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Sophie Palmer,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Jeff Almeida,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Sarah Sims,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Laurens G Wilming,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Jane Rogers,

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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• Pieter J. de Jong,

  Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America

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• Mary Carrington,

  Affiliation Basic Research Program, SAIC-Frederick, Inc., Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America

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• John F Elliott,

  Affiliation Alberta Diabetes Institute (ADI), Department of Medical Microbiology and Immunology, Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Canada

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• Stephen Sawcer,

  Affiliation Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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• John A Todd,

  Affiliation Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, United Kingdom

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• John Trowsdale,

  Affiliation Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom

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•  [ ... ],
• Stephan Beck

  *To whom correspondence should be addressed. E-mail: beck@sanger.ac.uk

  Affiliation Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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