Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss

Stéphane Richard; Nazi Torabi; Gladys Valverde Franco; Guy A Tremblay; Taiping Chen; Gillian Vogel; Mélanie Morel; Patrick Cléroux; Alexandre Forget-Richard; Svetlana Komarova; Michel L Tremblay; Wei Li; Ailian Li; Yun Jing Gao; Janet E Henderson

doi:10.1371/journal.pgen.0010074

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Peer-reviewed

Research Article

Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss

Stéphane Richard ,

*To whom correspondence should be addressed. E-mail: stephane.richard@ mcgill.ca

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Nazi Torabi,

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Gladys Valverde Franco,

Affiliations Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Guy A Tremblay,

Current address: INRS-Institut Armand-Frappier, Laval, Canada

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Taiping Chen,

Current address: INRS-Institut Armand-Frappier, Laval, Canada

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Gillian Vogel,

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Mélanie Morel,

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Patrick Cléroux,

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Alexandre Forget-Richard,

Affiliations Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Svetlana Komarova,

Affiliations Faculty of Dentistry, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Michel L Tremblay,

Affiliations McGill Cancer Centre and Department of Biochemistry, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Wei Li,

Affiliations Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Ailian Li,

Affiliations Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Yun Jing Gao,

Affiliations Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯
Janet E Henderson

Affiliations Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Montréal, Québec, Canada , Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Departments of Medicine and Oncology, McGill University, Montréal, Québec, Canada
⨯

Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss

Stéphane Richard,
Nazi Torabi,
Gladys Valverde Franco,
Guy A Tremblay,
Taiping Chen,
Gillian Vogel,
Mélanie Morel,
Patrick Cléroux,
Alexandre Forget-Richard,
Svetlana Komarova

Published: December 16, 2005
https://doi.org/10.1371/journal.pgen.0010074

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