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VARIABLE RISK OF GALLBLADER CANCER ACCORDING TO ETHNIC GROUP

Posted by cmengoa on 11 Jun 2017 at 16:53 GMT

When speaking of Native American ancestry individuals are considered as belonging to a homogeneous genotype with little variability, and therefore it is considered that their predisposition to certain diseases is similar, however this does not seem to be so, according to this interesting article , Where it is clearly established that there is a differentiated predisposition for certain pathologies between two distinctly defined Native American populations, the Mapuche to the south of Chile and the Aymara to the North, separated from each other several hundred kilometers by the way.
Perhaps this finding could explain why in Peru, there are marked differences in the incidence of gallbladder cancer among the different regions of the country. Thus, the Lima Cancer Registry reports a low incidence (5.2 / 100,000 for women) (1), while the Arequipa Registry reports a very high incidence (13.9 / 100,000 for women) (2).
All this knowing that Peru is a predominantly mestizo country with an important and homogeneous Native American component in all its territory (3), suggesting that these differences could be due to different degrees of suceptibidad in different regions of the country with different native populations.

1. Neoplasms, Department of Epidemiology National Institute of Diseases. Cancer Registry of Metropolitan Lima 2004 - 2005. Lima: s.n., 2006.
2. Arequipa, Cancer Population Registry of. Report of the Population Registry of Arequipa 2002 - 2003. Arequipa: s.n., 2004.
3. Geographic Patterns of Genome Admixture in Latin American Mestizos. Sijia Wang, Nicolas Ray, Winston Rojas, Maria V. Parra, Gabriel Bedoya. March 2008, PLOS Genetics.

No competing interests declared.
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