Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

Anita L. Manogaran; Joo Y. Hong; Joan Hufana; Jens Tyedmers; Susan Lindquist; Susan W. Liebman

doi:10.1371/journal.pgen.1001386

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Peer-reviewed

Research Article

Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

Anita L. Manogaran,

Affiliations Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America
⨯
Joo Y. Hong,

Affiliation Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Joan Hufana,

Affiliation Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois, United States of America
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Jens Tyedmers,

Affiliations Zentrum fuer Molekulare Biologie Heidelberg, DKFZ-ZMBH-Alliance, Universitaet Heidelberg, Heidelberg, Germany, Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Susan Lindquist,

Affiliation Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Susan W. Liebman

* E-mail: SueL@uic.edu

Affiliation Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯

Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

Anita L. Manogaran,
Joo Y. Hong,
Joan Hufana,
Jens Tyedmers,
Susan Lindquist,
Susan W. Liebman

Published: May 19, 2011
https://doi.org/10.1371/journal.pgen.1001386

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Polyglutamine toxicity in [pin-] cells

Posted by Alexvir on 21 May 2012 at 06:09 GMT

I thoroughly enjoyed reading this article and it is a very nice piece of work. I have noticed that the authors state that Q103 production in [pin-] and dRnq1 is untoxic. However, examination of the results indicates that there is a small degree of toxicity in these strains, albeit it is much less severe than in [pin-] strains. Our recent paper in PLOS One (http://www.plosone.org/ar...) shows that Q103 can polymerize in a [pin-] background, albeit less efficiently than in [PIN+] thus the reason for weak toxicity is quite clear.

No competing interests declared.

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Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes

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Polyglutamine toxicity in [pin-] cells

Posted by Alexvir on 21 May 2012 at 06:09 GMT