Reader Comments
Post a new comment on this article
Post Your Discussion Comment
Please follow our guidelines for comments and review our competing interests policy. Comments that do not conform to our guidelines will be promptly removed and the user account disabled. The following must be avoided:
- Remarks that could be interpreted as allegations of misconduct
- Unsupported assertions or statements
- Inflammatory or insulting language
Thank You!
Thank you for taking the time to flag this posting; we review flagged postings on a regular basis.
closecitation missing
Posted by jimhaber on 19 Feb 2013 at 23:07 GMT
Horowitz, H, P Thorburn and JE Haber (1984) Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae. MCB 4(11):2509-17.
This paper anticipates the conclusion of the authors that in meiosis only subtelomeric regions exhibit rearrangements.
RE: citation missing
PLOS_Genetics replied to jimhaber on 08 Mar 2013 at 17:00 GMT
"The following correspondence has been handed to the journal to upload by the authors, Eric Alani and Lars Steinmetz"
Dear PLoS Genetics,
When we wrote our paper we did not at the time think that the telomere instability phenotype observed in our mutation accumulation experiments (both in the vegetative and meiotic lines) was a novel observation (see cited Ref. 54-57 in our paper). We agree that Horowitz et al. (1984) describe the instability of telomere sequences in meiosis (reviewed in Ref. 54) and would have more explicitly cited the paper if we were aware of it. We apologize for this oversight.
Below is our e-mail exchange between Eric Alani and Jim Haber to resolve the issue:
From Eric Alani to Jim Haber: I now looked at your paper and see your Figure 6-spore progeny from an isogenic diploid. Yes, I see that you found changes in the Y-homologous fragment. I agree that your paper indicates subtelomeric rearrangements occur during meiosis (again I'm sorry that we missed citing it) but it doesn't seem to argue that the rest of the genome is stable as I interpret from your note. Am I missing something or is this just a wording issue?
From Jim Haber to Eric Alani: No, you are right. We didn't have any evidence about the rest of the genome and I wasn't suggesting otherwise, but we did show 30 years ago (!) that the ends were subject to frequent rearrangements.
Sincerely, Eric Alani and Lars Steinmetz