Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

David Zada; Adi Tovin; Tali Lerer-Goldshtein; Gad David Vatine; Lior Appelbaum

doi:10.1371/journal.pgen.1004615

Loading metrics

Open Access

Peer-reviewed

Research Article

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

David Zada ,

Contributed equally to this work with: David Zada, Adi Tovin

Affiliations The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
⨯
Adi Tovin ,

Contributed equally to this work with: David Zada, Adi Tovin

Affiliations The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
⨯
Tali Lerer-Goldshtein,

Affiliations The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
⨯
Gad David Vatine,

Affiliations The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel, Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Lior Appelbaum

* E-mail: lior.appelbaum@biu.ac.il

Affiliations The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
⨯

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

David Zada,
Adi Tovin,
Tali Lerer-Goldshtein,
Gad David Vatine,
Lior Appelbaum

Published: September 25, 2014
https://doi.org/10.1371/journal.pgen.1004615

Reader Comments

Post a new comment on this article

Heterozygous phenotypes in the locomotor and other assays?

Posted by rihel on 19 Oct 2014 at 10:25 GMT

I am wondering about any heterozygous phenotypes in any of the studies, in particular in the sleep:wake assay. These are claimed to be wt vs. mutant siblings placed in the tracking system. Does this mean there is a way to tell *before* you put the larvae into the experiment which ones are mutant and which ones are wild type? Or are the fish tracked blindly and then genotyped afterwards, in which case there will be heterozygous fish data that is being ignored in the analysis, or not reported? Thanks.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Larvae
Is the Subject Area "Larvae" applicable to this article?

Thanks for your feedback.
Zebrafish
Is the Subject Area "Zebrafish" applicable to this article?

Thanks for your feedback.
Embryos
Is the Subject Area "Embryos" applicable to this article?

Thanks for your feedback.
Axons
Is the Subject Area "Axons" applicable to this article?

Thanks for your feedback.
Motor neurons
Is the Subject Area "Motor neurons" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Sleep
Is the Subject Area "Sleep" applicable to this article?

Thanks for your feedback.
Synapses
Is the Subject Area "Synapses" applicable to this article?

Thanks for your feedback.

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Heterozygous phenotypes in the locomotor and other assays?

Posted by rihel on 19 Oct 2014 at 10:25 GMT