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Apparently different recommendations for p12 in the paper

Posted by mtalaei on 19 Dec 2022 at 14:12 GMT

I got confused with the recommended p12 in the 2nd paragraph of the discussion and the conclusions:
2nd paragraph of discussion: "Perhaps the most widely applicable are the results of simulations, that suggest values of the order p12 ≈ 5×10−6 lead to robust inference over a range of scenarios, but the adoption of sensitivity analysis will help evaluate robustness of inference to changes in prior parameter values."
In summary: "The simulations here (Fig (4)) suggest that p12 = 5×10−5 provides a reasonable balance between power and false positive calls..."
It is clear that sensitivity analysis is required at least for key results, but if we need a single number I assume that the one in the conclusion is the final recommendation: p12 = 5×10−5.

No competing interests declared.

RE: Apparently different recommendations for p12 in the paper

ChrisWallace replied to mtalaei on 22 Dec 2022 at 15:35 GMT

This is a mistake. The 5 x 10-6 is correct. I will get in touch with the journal to ask them to fix this.

Competing interests declared: Part time employee of GSK; GSK have had no involvement in this study, paper, or response.