Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Paula Dietrich; Irudayam Maria Johnson; Shanta Alli; Ioannis Dragatsis

doi:10.1371/journal.pgen.1006846

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Research Article

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Paula Dietrich,

Affiliation Department of Physiology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America
⨯
Irudayam Maria Johnson,

Current address: Department of Pediatrics, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America

Affiliation Department of Physiology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America

http://orcid.org/0000-0003-4255-4477

⨯
Shanta Alli,

Current address: Department of Ophthalmology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America

Affiliation Department of Physiology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America
⨯
Ioannis Dragatsis

* E-mail: idragatsis@uthsc.edu

Affiliation Department of Physiology, The University of Tennessee, Health Science Center, Memphis, Tennessee, United States of America

http://orcid.org/0000-0003-4087-4813

⨯

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Paula Dietrich,
Irudayam Maria Johnson,
Shanta Alli,
Ioannis Dragatsis

Published: July 17, 2017
https://doi.org/10.1371/journal.pgen.1006846

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Publisher's Note: Editor's Affiliation

Posted by PLOS_Genetics on 16 Aug 2017 at 13:21 GMT

There is an error in the editor’s affiliation. The correct affiliation for Tom Vogt is CHDI Management, United States. The journal notes that the authors were supported by CHDI Foundation. The editor had no role in CHDI Foundation’s decision to fund this research.

No competing interests declared.

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Neostriatum
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Calcification
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Mice
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Huntington disease
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Weight gain
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Thalamus
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Polymerase chain reaction
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Animal behavior
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Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

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Publisher's Note: Editor's Affiliation

Posted by PLOS_Genetics on 16 Aug 2017 at 13:21 GMT