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closeClarification by the authors: MEME is not just an exploratory tool
Posted by kscheffler on 06 Mar 2013 at 22:02 GMT
In the section "Detecting individual branches subject to diversifying selection at a given site" of this paper we stated the caveat that "we do not recommend using this type of inference other than for the purposes of data exploration". This was intended to warn users against potentially overinterpreting the specific set of branches inferred to be under positive selection for a single episodically selected site, for which the data are, of necessity, not very informative. However, it has come to our attention that this caveat has been interpreted (incorrectly) as referring to MEME in general (inference at an individual site over multiple branches) rather than to inference at an individual branch-site combination as intended. We would like to clarify that the available MEME analysis tools are intended and have been validated for hypothesis testing and not just exploratory analysis.