Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

• Sandosh Padmanabhan,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Olle Melander,

  Affiliation Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden

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• Toby Johnson,

  Affiliation Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

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• Anna Maria Di Blasio,

  Affiliation Istituto Auxologico Italiano, Milan, Italy

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• Wai K. Lee,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Davide Gentilini,

  Affiliation Istituto Auxologico Italiano, Milan, Italy

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• Claire E. Hastie,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Cristina Menni,

  Affiliations Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Università Milano-Bicocca, Dipartimento di Medicina Clinica e Prevenzione, Ospedale San Gerardo, Monza, Milano, Italy

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• Maria Cristina Monti,

  Affiliations Istituto Auxologico Italiano, Milan, Italy, Department of Health Science, University of Pavia, Pavia, Italy

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• Christian Delles,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Stewart Laing,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Barbara Corso,

  Affiliations Istituto Auxologico Italiano, Milan, Italy, Department of Health Science, University of Pavia, Pavia, Italy

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• Gerjan Navis,

  Affiliation Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Arjan J. Kwakernaak,

  Affiliation Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Pim van der Harst,

  Affiliation Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Murielle Bochud,

  Affiliation University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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• Marc Maillard,

  Affiliation Service of Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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• Michel Burnier,

  Affiliation Service of Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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• Thomas Hedner,

  Affiliation Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Sverre Kjeldsen,

  Affiliation Department of Cardiology, University of Oslo, Ullevaal Hospital, Oslo, Norway

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• Björn Wahlstrand,

  Affiliation Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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• Marketa Sjögren,

  Affiliation Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden

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• Cristiano Fava,

  Affiliations Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden, Department of Medicine, Section of Internal Medicine C, University of Verona, Verona, Italy

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• Martina Montagnana,

  Affiliations Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden, Department of Life and Reproduction Sciences, Section of Clinical Chemistry, University of Verona, Verona, Italy

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• Elisa Danese,

  Affiliations Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden, Department of Life and Reproduction Sciences, Section of Clinical Chemistry, University of Verona, Verona, Italy

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• Ole Torffvit,

  Affiliation Department of Nephrology, Institution of Clinical Sciences, University Hospital of Lund, Lund, Sweden

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• Bo Hedblad,

  Affiliation Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden

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• Harold Snieder,

  Affiliation Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• John M. C. Connell,

  Affiliation College of Medicine, Dentistry and Nursing, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

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• Morris Brown,

  Affiliation Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom

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• Nilesh J. Samani,

  Affiliation Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom

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• Martin Farrall,

  Affiliation Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

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• Giancarlo Cesana,

  Affiliation Università Milano-Bicocca, Dipartimento di Medicina Clinica e Prevenzione, Ospedale San Gerardo, Monza, Milano, Italy

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• Giuseppe Mancia,

  Affiliation Università Milano-Bicocca, Dipartimento di Medicina Clinica e Prevenzione, Ospedale San Gerardo, Monza, Milano, Italy

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• Stefano Signorini,

  Affiliation Azienda Ospedaliera di Desio e Vimercate, Milano, Italy

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• Guido Grassi,

  Affiliation Università Milano-Bicocca, Dipartimento di Medicina Clinica e Prevenzione, Ospedale San Gerardo, Monza, Milano, Italy

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• Susana Eyheramendy,

  Affiliation Department of Statistics, Pontificia Universidad Catolica de Chile, Santiago, Chile

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• H. Erich Wichmann,

  Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany

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• Maris Laan,

  Affiliation Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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• David P. Strachan,

  Affiliation Division of Community Health Sciences, St George's, University of London, London, United Kingdom

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• Peter Sever,

  Affiliation International Centre for Circulatory Health National Heart and Lung Institute, Imperial College, London, United Kingdom

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• Denis Colm Shields,

  Affiliation Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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• Alice Stanton,

  Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Peter Vollenweider,

  Affiliation Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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• Alexander Teumer,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

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• Henry Völzke,

  Affiliation Institute for Community Medicine, University of Greifswald, Greifswald, Germany

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• Rainer Rettig,

  Affiliation Institute of Physiology, University of Greifswald, Greifswald, Germany

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• Christopher Newton-Cheh,

  Affiliations Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Pankaj Arora,

  Affiliations Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• Feng Zhang,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Nicole Soranzo,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, United Kingdom

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• Timothy D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Gavin Lucas,

  Affiliation Cardiovascular Epidemiology and Genetics Group, Institut Municipal d'Investigacio Medica, Barcelona, Spain

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• Sekar Kathiresan,

  Affiliations Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

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• David S. Siscovick,

  Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

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• Jian'an Luan,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

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• Ruth J. F. Loos,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

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• Nicholas J. Wareham,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom

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• Brenda W. Penninx,

  Affiliations Department of Psychiatry/EMGO Institute, Neuroscience Campus, VU University Medical Center, Amsterdam, The Netherlands, Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Ilja M. Nolte,

  Affiliation Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Martin McBride,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• William H. Miller,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Stuart A. Nicklin,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Andrew H. Baker,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Delyth Graham,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Robert A. McDonald,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Jill P. Pell,

  Affiliation Public Health and Health Policy Section, University of Glasgow, Glasgo, United Kingdom

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• Naveed Sattar,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Paul Welsh,

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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• Global BPgen Consortium ,

  ¶For more information on the Global BPgen Consortium please see Text S1.

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• Patricia Munroe,

  Affiliation Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

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• Mark J. Caulfield,

  Affiliation Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom

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• Alberto Zanchetti,

  Affiliations Istituto Auxologico Italiano, Milan, Italy, University of Milano, Milano, Italy

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•  [ ... ],
• Anna F. Dominiczak

  * E-mail: anna.dominiczak@glasgow.ac.uk

  Affiliation Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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