About the Authors

Ralitsa R. Madsen

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

r.madsen@ucl.ac.uk

Affiliation University College London Cancer Institute, Paul O’Gorman Building, University College London, London, United Kingdom

Emily C. Erickson

Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

Affiliation Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Oscar M. Rueda

Roles Supervision, Writing – review & editing

Affiliations Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom, Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Xavier Robin

Roles Supervision, Writing – review & editing

Affiliation SIB Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Basel, Switzerland

Carlos Caldas

Roles Funding acquisition, Resources

Affiliations Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom, Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom

Alex Toker

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Robert K. Semple

Contributed equally to this work with: Robert K. Semple, Bart Vanhaesebroeck

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

Bart Vanhaesebroeck

Contributed equally to this work with: Robert K. Semple, Bart Vanhaesebroeck

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation University College London Cancer Institute, Paul O’Gorman Building, University College London, London, United Kingdom

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: R.K.S. consults for Novartis (Cambridge, MA, USA) on use of PI3K inhibitors in overgrowth syndromes and has consulted for HotSpot Therapeutics (Boston, MA, USA); B.V. is a consultant for iOnctura (Geneva, Switzerland), Venthera (Palo Alto, CA, USA), Olema Pharmaceuticals (San Francisco, US) and Pharming (Leiden, The Netherlands).